High-Sensitivity Enzymatic Glucose Sensor Based on ZnO Urchin-like Nanostructure Modified with Fe₃O₄ Magnetic...

Area of Science:

• Nanomaterials Science
• Biosensor Technology
• Electrochemistry

Background:

• Development of sensitive and selective glucose sensors is crucial for diabetes management.
• Existing enzymatic glucose sensors face challenges in sensitivity, stability, and interference.

Purpose of the Study:

• To fabricate a novel enzymatic glucose sensor with enhanced performance.
• To investigate the synergistic effects of iron oxide magnetic nanoparticles (Fe3O4MNPs) and ZnO nanoflowers (ZnONFs) on sensor efficiency.

Main Methods:

• Urchin-like ZnO nanoflowers (ZnONFs) were synthesized on a flexible PET substrate.
• Fe3O4MNPs were deposited onto ZnONFs via drop-coating.
• Glucose oxidase (GOx) was immobilized on the modified substrate.
• Electrochemical performance was evaluated using cyclic voltammetry and amperometry.

Main Results:

• The Fe3O4MNPs significantly promoted electron transfer and H2O2 hydrolysis, enhancing catalytic efficiency.
• The fabricated sensor achieved a high sensitivity of 4.52 μA·mM⁻¹·cm⁻², a 7.93-fold improvement over sensors without Fe3O4MNPs.
• The sensor demonstrated excellent anti-interference capabilities against common biological compounds and salts, and maintained 80% performance after 20 reuses.

Conclusions:

• The integration of Fe3O4MNPs with ZnONFs offers a promising strategy for developing highly sensitive and stable enzymatic glucose biosensors.
• The optimized electron transfer and catalytic efficiency contribute to the superior performance of the proposed glucose sensor.
• This approach provides valuable insights for enhancing the performance of other enzymatic biosensor systems.