Capillary Electrophoresis as a Monitoring Tool for Flow Composition Determination

Area of Science:

• Analytical Chemistry
• Process Monitoring

Background:

• Flow analysis involves quantitative chemistry in fluid streams.
• Capillary electrophoresis (CE) is efficient for analyzing flowing samples from processes like bioreactors and microdialysis.

Purpose of the Study:

• To review innovative methods for interfacing flow streams with capillary electrophoresis instruments.
• To identify challenges and applications of CE in flow analysis.

Main Methods:

• Review of various computer-controlled autosampler-like interfaces for CE.
• Analysis of existing literature on CE interfacing for bioprocesses.

Main Results:

• Several ingenious CE interfacing approaches are presented.
• Despite sample waste in some methods, important applications exist.
• Commercial device scarcity limits widespread CE flow analysis.

Conclusions:

• Interfacing CE for flow analysis requires further investigation.
• The lack of commercial devices presents a research opportunity for developing new CE flow sampling techniques.