Related Experiment Video

Updated: Oct 22, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.2K

Current Status, Distribution, and Future Directions of Natural Products against Colorectal Cancer in Indonesia: A

Didi Nurhadi Illian1, Ihsanul Hafiz2, Okpri Meila1

  • 1Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Molecules (Basel, Switzerland)
|August 27, 2021
PubMed

Insights

Natural products show potential as alternative colorectal cancer treatments in Indonesia. This review highlights terpenoids and other compounds, suggesting future co-chemotherapy applications and aiding drug discovery.

Area of Science:

  • Natural Product Chemistry
  • Oncology
  • Pharmacology

Background:

  • Colorectal cancer is a significant global health burden, with millions diagnosed and dying annually.
  • Conventional treatments like chemotherapy and radiation have limitations, driving interest in alternative therapies.
  • Natural products are increasingly explored for their potential therapeutic benefits in cancer treatment.

Purpose of the Study:

  • To review the current status and distribution of natural products in Indonesia with potential activity against colorectal cancer.
  • To identify promising natural compounds and assess their potential as alternative or complementary treatments.
  • To explore future implications for colorectal cancer management in Indonesia.

Main Methods:

  • A systematic review of 38 studies was conducted.
  • Data on natural products, their distribution in Indonesia, and cytotoxic activity against colorectal cancer cell lines were extracted.
  • Commonly used methods included MTT assays and other in vitro/in vivo analyses.

Main Results:

  • Terpenoids were the predominant class of natural products with activity against colorectal cancer cells, followed by phytosterols, phenolics, alkaloids, and polyisoprenoids.
  • WiDr, HT-29, and HCT-116 were frequently used cell lines for cytotoxicity testing.
  • MTT assays were the most common method for evaluating cytotoxic activity.

Conclusions:

  • Several Indonesian natural products, particularly terpenoids, show promise as alternative treatments for colorectal cancer.
  • These compounds may serve as future co-chemotherapy agents, requiring further research on safety, quality, and standardization.
  • Computational methods are advancing drug discovery for natural product-based therapies.
Keywords:
IndonesiaMTTWiDrcolorectal cancernatural productpolyisoprenoidsterpenoids

More Related Videos

Fast Inspection of Quality of Indigo Naturalis by Multiple Light Scattering03:40

Fast Inspection of Quality of Indigo Naturalis by Multiple Light Scattering

Published on: August 18, 2023

579
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.8K

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
277
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K