Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Area of Science:

• Biomaterials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Electrospinning utilizes polymer solutions and electric fields to create nanofibers.
• Electrospun nanofibers possess large surface areas, tunable properties, and high biocompatibility.
• These characteristics make them suitable for various biomedical applications, including drug delivery.

Purpose of the Study:

• To review the concept and recent advancements in electrospinning for drug delivery systems.
• To explore the detailed encapsulation of nutraceuticals, with a specific focus on probiotics, using electrospun nanofibers.

Main Methods:

• Discussion of the electrospinning technique for nanofiber production.
• Review of literature on the application of electrospun nanofibers in drug delivery formulations.
• Analysis of strategies for encapsulating nutraceuticals, particularly probiotics, within electrospun matrices.

Main Results:

• Electrospinning enables the formulation of poorly soluble drugs into amorphous solid dispersions, improving solubility and bioavailability.
• The method facilitates targeted drug release and enhances the efficacy of drug delivery systems.
• Successful strategies for the encapsulation of nutraceuticals, including probiotics, have been demonstrated.

Conclusions:

• Electrospun nanofibers represent a promising material for developing advanced drug delivery systems.
• The technology offers significant potential for improving the delivery and efficacy of both pharmaceuticals and nutraceuticals.
• Further research into electrospun probiotics holds promise for innovative health solutions.