Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.1K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.1K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

3.5K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.5K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

3.0K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
3.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.2K
Introduction to Electrolytes01:33

Introduction to Electrolytes

13.9K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
13.9K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

521
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
521

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of the Internet of Things for Improving Health of Non-Pregnant Women Living in High-Income Countries: A Systematic Review.

Healthcare (Basel, Switzerland)·2025
Same author

Prevalence of Cervical Cancer Screening in Asia: A Systematic Review and Meta-Analysis.

Asian Pacific journal of cancer prevention : APJCP·2025
Same author

Effectiveness of the Internet of Things for Improving Pregnancy and Postpartum Women's Health in High-Income Countries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Healthcare (Basel, Switzerland)·2025
Same author

Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium.

Journal of epidemiology·2025
Same author

Reproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium.

Cancer prevention research (Philadelphia, Pa.)·2025
Same author

Prevalence of Breast Cancer Screening in Asia: Systematic Review and Meta-Analysis.

Asian Pacific journal of cancer prevention : APJCP·2024

Related Experiment Video

Updated: Oct 22, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K

Polymorphisms Contributing to Calcium Status: A Systematic Review.

Katharina da Silva Lopes1, Sarah Krull Abe2

  • 1Graduate School of Public Health, St. Luke's International University, Tokyo 104-0045, Japan.

Nutrients
|August 27, 2021
PubMed
Summary
This summary is machine-generated.

This review found genetic variations, specifically Single Nucleotide Polymorphisms (SNPs) in genes like CASR and VDR, are linked to calcium status. Further research is needed to guide dietary recommendations based on these genetic links.

Keywords:
SNPscalcium homeostasiscalcium requirementsgenetic factorspolymorphism

More Related Videos

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

15.1K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.8K

Related Experiment Videos

Last Updated: Oct 22, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K
Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

15.1K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.8K

Area of Science:

  • Genetics and Molecular Biology
  • Nutritional Science
  • Human Physiology

Background:

  • Calcium homeostasis is crucial for health.
  • Genetic variations can influence calcium metabolism.
  • Understanding these links can inform health strategies.

Purpose of the Study:

  • To systematically review genetic variations affecting calcium homeostasis.
  • To identify specific gene polymorphisms associated with calcium status.
  • To assess the quality of existing research in this field.

Main Methods:

  • Systematic literature search of EMBASE, Medline, and CENTRAL.
  • Inclusion of studies on human populations and calcium metabolism genes.
  • Data extraction and quality assessment using the Q-Genie tool.

Main Results:

  • Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) were identified.
  • Significant associations were found between SNPs in CASR, VDR, and other genes with calcium status.
  • Most studies focused on Caucasian adults, with varying study designs and quality.

Conclusions:

  • Several gene SNPs, particularly in CASR and VDR, are associated with calcium status.
  • Further research is required to establish clear links for dietary recommendations.
  • Investigating common polymorphisms and calcium requirements is essential.