Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium

Area of Science:

• Cardiovascular epidemiology
• Public health research
• Chronic disease management

Background:

• Most multimorbidity mortality studies focus on Western populations.
• Limited data exists on cardiometabolic multimorbidity in Asian cohorts.
• This study addresses the association in the Asia Cohort Consortium.

Purpose of the Study:

• To investigate the link between cardiometabolic multimorbidity and mortality in Asian populations.
• To differentiate mortality risks associated with individual cardiometabolic diseases and their combinations.
• To inform targeted prevention and management strategies.

Main Methods:

• Prospective cohort study utilizing pooled analysis from 11 Asian cohorts.
• Evaluated associations between hypertension, diabetes, ischemic heart disease, stroke, multimorbidity, and mortality.
• Hazard ratios (HRs) and 95% confidence intervals (CIs) estimated via Cox regression.

Main Results:

• Analysis included 483,532 participants with a median follow-up of 14.3 years.
• Stroke and diabetes showed significantly higher HRs for all-cause mortality (HR 3.9).
• Stroke, ischemic heart disease, and diabetes had the highest HRs for CVD mortality (HR 10.6).
• Premature mortality risks were more pronounced, following similar trends.

Conclusions:

• Individual cardiometabolic diseases and their combinations have distinct impacts on mortality.
• Stroke and diabetes pose the greatest risks for all-cause and cardiovascular mortality in Asians.
• Highlights the need for tailored prevention and management for these conditions in Asian populations.