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Urinary Potassium and Kidney Function Decline in the Population-Observational Study.

Massimo Cirillo1, Giancarlo Bilancio2, Pierpaolo Cavallo3

  • 1Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy.

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Summary
This summary is machine-generated.

High potassium intake may protect kidney function over time. This study found urinary potassium did not correlate with kidney function at one point but was linked to slower decline in estimated glomerular filtration rate (eGFR) over years.

Keywords:
eGFRepidemiologypotassium

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Area of Science:

  • Nephrology
  • Epidemiology
  • Nutritional Science

Background:

  • Growing evidence suggests high potassium intake benefits kidney health.
  • Population-based studies are needed to clarify the relationship between potassium and kidney function over time.

Purpose of the Study:

  • To investigate the cross-sectional and longitudinal associations between urinary potassium levels and kidney function in a large population cohort.
  • To determine if potassium intake influences the decline of estimated glomerular filtration rate (eGFR) with age.

Main Methods:

  • A cohort of 2027 adults from the Gubbio Study provided data across three exams (1983-2007).
  • Urinary potassium was measured as the potassium/creatinine ratio in spot and timed samples.
  • Estimated glomerular filtration rate (eGFR) was assessed at all exams, with adjustments for various demographic and lifestyle factors.

Main Results:

  • Urinary potassium/creatinine ratio showed no cross-sectional association with eGFR at baseline or follow-up.
  • Higher urinary potassium levels at baseline predicted a slower decline in eGFR over the subsequent study periods.
  • Elevated urinary potassium was associated with a reduced incidence of severely impaired kidney function (eGFR < 60 mL/min/1.73 m²).

Conclusions:

  • Urinary potassium levels are not associated with current kidney function but are linked to a slower rate of kidney function decline over time.
  • These findings support a protective role for potassium intake in mitigating age-related kidney function deterioration.