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Updated: Oct 22, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Role of the APRIL molecule in solid tumors

Kinga Henryka Nowacka1, Ewa Jabłońska1

  • 1Department of Immunology, Medical University of Bialystok, J. Waszyngtona 15A, 15-269 Białystok, Poland.

Cytokine & Growth Factor Reviews
|August 27, 2021
PubMed

Insights

The APRIL molecule promotes cancer cell survival and proliferation. Targeting APRIL may offer new diagnostic and therapeutic strategies for various human cancers.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The APRIL molecule is implicated in cancer cell survival and proliferation.
  • APRIL is produced by immune cells, their precursors, and cancer cells.
  • Understanding APRIL's role is crucial for cancer research.

Purpose of the Study:

  • To review the effects of APRIL on human cancer development.
  • To elucidate the mechanism of APRIL's action in solid tumors.
  • To explore APRIL's potential as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of current knowledge on APRIL and cancer.
  • Development of a mechanistic scheme for APRIL's action on solid tumors.
  • Analysis of correlations between APRIL levels and cancer parameters.

Main Results:

  • APRIL influences cancer cell survival and proliferation.
  • APRIL's intracellular signal transduction pathways are under investigation.
  • Observed correlations link APRIL levels to disease stage and malignant phenotypes.

Conclusions:

  • APRIL plays a significant role in human cancer development.
  • APRIL's mechanism of action provides insights into cancer progression.
  • APRIL shows potential as a diagnostic biomarker and therapeutic target in oncology.
Keywords:
A Proliferation-inducing ligandCancerTALL-2TNFSF13

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