Hypoxic-Ischemic Encephalopathy-Induced Seizure in an 11-Year-Old Female

Krunal Pandav1, Angela Ishak1, Farah Chohan2

  • 1Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, USA.

Cureus
|August 27, 2021
PubMed

Insights

Hypoxic-ischemic encephalopathy (HIE) can affect individuals beyond infancy, leading to seizures due to brain changes from birth asphyxia. Understanding late-onset HIE is crucial for effective long-term patient management and improved outcomes.

Area of Science:

  • Neurology
  • Neonatology
  • Pediatrics

Background:

  • Hypoxic-ischemic encephalopathy (HIE) is a neonatal condition often resulting from intrapartum asphyxia.
  • Brain structural changes from HIE can lead to long-term functional deficits, including developmental delays and epilepsy.

Observation:

  • A rare case of an 11-year-old female with a history of epilepsy and cerebral atrophy due to birth-related HIE is presented.
  • The patient experienced a witnessed seizure and loss of consciousness, indicative of an encephalopathic process.

Findings:

  • The patient's history of HIE contributed to a lower seizure threshold, manifesting as a recent prolonged seizure.
  • This case highlights that HIE's effects can persist and manifest clinically well beyond the neonatal period.

Implications:

  • Recognizing HIE's potential for late-onset manifestations is vital for accurate diagnosis and management in older children.
  • Understanding the neurobiological sequelae of HIE is essential for improving long-term care and patient outcomes.

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
385
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
706
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
372