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Published on: June 11, 2020
Hypoxic-Ischemic Encephalopathy-Induced Seizure in an 11-Year-Old Female
Krunal Pandav1, Angela Ishak1, Farah Chohan2
1Division of Research & Academic Affairs, Larkin Community Hospital, South Miami, USA.
Insights
Hypoxic-ischemic encephalopathy (HIE) can affect individuals beyond infancy, leading to seizures due to brain changes from birth asphyxia. Understanding late-onset HIE is crucial for effective long-term patient management and improved outcomes.
Area of Science:
- Neurology
- Neonatology
- Pediatrics
Background:
- Hypoxic-ischemic encephalopathy (HIE) is a neonatal condition often resulting from intrapartum asphyxia.
- Brain structural changes from HIE can lead to long-term functional deficits, including developmental delays and epilepsy.
Observation:
- A rare case of an 11-year-old female with a history of epilepsy and cerebral atrophy due to birth-related HIE is presented.
- The patient experienced a witnessed seizure and loss of consciousness, indicative of an encephalopathic process.
Findings:
- The patient's history of HIE contributed to a lower seizure threshold, manifesting as a recent prolonged seizure.
- This case highlights that HIE's effects can persist and manifest clinically well beyond the neonatal period.
Implications:
- Recognizing HIE's potential for late-onset manifestations is vital for accurate diagnosis and management in older children.
- Understanding the neurobiological sequelae of HIE is essential for improving long-term care and patient outcomes.
Abstract:
Hypoxic-ischemic encephalopathy (HIE) typically manifests in the neonatal period. The degree of hypoxia following intrapartum asphyxia determines the structural changes in the brain, which can cause functional deficits in the affected child leading to developmental deficits and recurrent seizures. Management requires physical therapy, occupational therapy, and anti-seizure medications. We present a rare case of an 11-year-old female with a past medical history of epilepsy and cerebral atrophy secondary to hypoxic injury at birth. The patient presented to the hospital following a witnessed seizure and loss of consciousness for one hour. Given the past medical history and clinical findings, it was determined that a mild-to-moderate encephalopathic process resulted in a lower seizure threshold. HIE can manifest beyond the neonate years mainly due to the structural changes within the brain. Therefore, it is essential to understand aspects of HIE beyond the neonate years to manage this condition for a better patient outcome.
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