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Updated: Oct 22, 2025

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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Published on: June 23, 2013

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The impact of non-coding RNAs on macrophage polarization

Soudeh Ghafouri-Fard1, Atefe Abak2, Shamim Tavakkoli Avval3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 27, 2021
PubMed

Insights

Macrophage polarization, a key immune process, is regulated by non-coding RNAs like miRNAs and lncRNAs. Understanding these interactions is crucial for developing therapies for immune disorders and cancer.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Macrophage polarization dictates immune cell function in response to environmental cues.
  • M1 and M2 macrophage phenotypes are induced by distinct stimuli, including cytokines and lipopolysaccharide.
  • Non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are emerging as critical regulators of this process.

Purpose of the Study:

  • To summarize current research on the role of non-coding RNAs in modulating macrophage polarization.
  • To highlight specific miRNAs and lncRNAs involved in M1/M2 polarization.
  • To underscore the therapeutic potential of targeting non-coding RNAs for immune-related diseases and cancer.

Main Methods:

  • Literature review of studies investigating non-coding RNA regulation of macrophage polarization.
  • Identification of key miRNAs (e.g., miR-375, miR-155, miR-124) and lncRNAs (e.g., H19, MEG3, GAS5) involved.
  • Analysis of the functional significance of these non-coding RNAs in macrophage phenotypes.

Main Results:

  • Numerous miRNAs and lncRNAs have been identified as regulators of macrophage polarization.
  • Specific non-coding RNAs are associated with either M1 or M2 macrophage phenotypes.
  • Drug-induced modulation of macrophage polarization often involves alterations in non-coding RNA expression.

Conclusions:

  • Non-coding RNAs are pivotal in controlling macrophage polarization.
  • Targeting specific non-coding RNAs offers a promising therapeutic strategy for immune disorders and cancer.
  • Further research into non-coding RNA mechanisms can advance the development of novel treatments.
Keywords:
LncRNAMacrophage polarizationMiRNA

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