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Related Experiment Video

Updated: Oct 22, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Panniculitis in Children.

Isabelle Moulonguet^1,2, Sylvie Fraitag³

¹Cabinet de Dermatopathologie Mathurin Moreau, 75019 Paris, France.

Dermatopathology (Basel, Switzerland)

|August 27, 2021

Summary

This summary is machine-generated.

Panniculitis, rare childhood inflammatory diseases of subcutaneous fat, present as tender nodules. Early screening for immune disorders is crucial for unexplained cases in young children.

Keywords:

autoinflammatory diseases histopathology panniculitis

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Area of Science:

Pediatric Dermatology
Rheumatology
Immunology

Background:

Panniculitides are diverse inflammatory conditions affecting subcutaneous adipose tissue.
While rare in children, they can be primary or secondary to other conditions.
Several new pediatric panniculitis entities have emerged recently.

Purpose of the Study:

To review childhood panniculitides, emphasizing newly described forms.
To highlight the diagnostic approach and classification of these rare disorders.
To underscore the importance of investigating immune disorders in children with unexplained panniculitis.

Main Methods:

Literature review focusing on pediatric panniculitis.
Analysis of clinical presentations, etiologies, and histopathology.
Discussion of the link between panniculitis and immune system disorders.

Main Results:

Panniculitis in children often presents as tender, erythematous subcutaneous nodules.
Lobular panniculitis is common in pediatric cases.
Panniculitis can be an early sign of autoimmune diseases and primary immunodeficiencies.

Conclusions:

Histopathological assessment is often necessary for diagnosis and classification.
Unexplained panniculitis in young children warrants screening for monogenic immune disorders.
Understanding newly described entities is vital for pediatric rheumatologists and dermatologists.