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Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications.

Francisco Romero-Gavilán1, Andreia Cerqueira2, Eduardo Anitua3,4,5

  • 1Department of Industrial Systems Engineering and Design, Universitat Jaume I, Campus del Ríu Sec, Av. Vicent Sos Baynat s/n, 12071, Castellón de la Plana, Spain. gavilan@uji.es.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
|August 28, 2021
PubMed
Summary

Calcium ions on titanium implants initially promote coagulation and inflammation. Their timed release alters protein adsorption, influencing biological responses like bone regeneration and osseointegration.

Keywords:
Bioinorganic chemistryBlood clottingDental implantsOsseointegrationProteomics

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Implantology

Background:

  • Calcium ions are crucial in biomaterials for enhancing coagulation, bone regeneration, and implant osseointegration.
  • The release kinetics of calcium ions from titanium implant surfaces impacts the implant-tissue interface's physicochemical properties and subsequent biological reactions.

Purpose of the Study:

  • To investigate the dynamic changes in protein adsorption on titanium surfaces with and without calcium ions over time.
  • To correlate protein adsorption patterns with biological responses, including osteogenic and inflammatory reactions.

Main Methods:

  • Titanium discs (with and without calcium) were incubated with human serum for varying durations (2, 180, 960 minutes).
  • Protein adsorption was analyzed using nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS).
  • In vitro studies with human osteoblasts and monocytes assessed osteogenic and inflammatory responses.

Main Results:

  • Differential protein adsorption kinetics were observed between calcium-modified and standard titanium surfaces.
  • An increase in proteins related to coagulation and immune responses was noted before calcium ion release.
  • Calcium-enriched surfaces exhibited significant initial inflammation, which subsided post-calcium release.
  • Implant-blood contact experiments confirmed enhanced coagulatory effects on calcium surfaces.

Conclusions:

  • The study elucidates distinct protein adsorption and desorption dynamics on calcium-ion modified titanium surfaces.
  • These dynamics explain the differing biological responses, including initial inflammation and subsequent osseointegration, between calcium-modified and standard titanium implants.
  • Understanding these temporal surface changes is key for designing effective dental and orthopedic implants.