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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue and dementia risk: A nationwide longitudinal study

Che-Sheng Chu¹, Shih-Jen Tsai², Chih-Ming Cheng²

¹Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan; Center for Geriatric and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan; Non-invasive Neuromodulation Consortium for Mental Disorders, Society of Psychophysiology, Taipei, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

The Journal of Infection

|August 29, 2021

Summary

Dengue infection significantly increases the risk of developing dementia, including Alzheimer's disease. This study highlights a crucial link between dengue fever and long-term neurocognitive decline.

Area of Science:

Neurology
Infectious Diseases
Epidemiology

Background:

Neurological complications are increasingly reported following dengue infection.
The long-term impact of dengue on neurocognitive health remains poorly understood.

Purpose of the Study:

To investigate the association between dengue infection and the subsequent risk of dementia.
To analyze specific dementia subtypes, including Alzheimer's and vascular dementia.

Main Methods:

A retrospective cohort study utilizing Taiwan's National Health Insurance Research Database (1997-2013).
816 dengue patients and 8,160 controls were analyzed using Cox regression.
Adjustments were made for demographic factors and comorbidities; sensitivity analyses were performed.

Main Results:

Dengue patients showed a 2.23-fold higher risk of developing dementia (HR: 2.23, 95% CI: 1.51-3.28).
Increased risk was observed for unspecified dementia (HR: 2.25) and Alzheimer's disease (HR: 3.03), but not vascular dementia.
Consistent findings across sensitivity analyses supported the association.

Conclusions:

Dengue infection is associated with a significantly elevated risk of subsequent dementia.
Further research is needed to elucidate the pathophysiological mechanisms linking dengue and dementia.

Keywords:

Alzheimer's disease Causality Dementia Dengue

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