[Hypolipidemic effect of the antivitamin B1 oxythiamine in diabetic mice (db/db)]

A rate of lipogenesis from 1-14C-acetate and 2-14C-pyruvate as well as total cholesterol, diene conjugates, malonic dialdehyde were increased in liver tissue of mice db/db strain with genetically determined diabetes, whereas content of free fatty acids was not distinctly altered despite of the marked elevation of corticosterone in blood plasma. Ratio of atherogenic lipoproteins VLDL and LDL was increased in blood plasma of these mice with diabetes. As oxythiamine, administered into the mice, exhibited hypolipidemic and antioxidant effects, TDP-dependent reactions appear to be among the factors responsible for deterioration of lipid metabolism in the diabetes.