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Recent advances in high-speed photoacoustic microscopy
Kaiyue Wang1, Chiye Li1, Ruimin Chen1
1Zhejiang Lab, Hangzhou, Zhejiang, 311121, China.
Photoacoustics
|August 30, 2021
Summary
High-speed photoacoustic microscopy (PAM) offers advanced biomedical imaging by combining light and sound. Recent technological progress enables faster, wider-field functional activity imaging in diverse applications.
Area of Science:
- Biomedical optics
- Acoustic imaging
- Microscopy technologies
Background:
- Photoacoustic microscopy (PAM) has rapidly advanced in biomedicine over the last decade.
- PAM is a versatile imaging modality with applications in hemodynamics, oncology, metabolism, and neuroimaging.
- Its hybrid optical excitation and acoustic detection offer rich contrast and deep tissue penetration.
Purpose of the Study:
- To review recent technological advancements in high-speed photoacoustic microscopy (PAM).
- To highlight progress in laser development, scanning techniques, and signal acquisition for high-speed PAM.
Main Methods:
- Review of high-repetition-rate multi-wavelength laser development for PAM.
- Analysis of fast scanning methodologies enabling high-speed PAM.
- Exploration of novel photoacoustic signal acquisition strategies.
Main Results:
- Significant progress in high-speed PAM technologies has been achieved.
- Developments include advanced lasers, rapid scanning, and efficient signal detection.
- These advances facilitate high-speed, wide-field imaging of functional activity.
Conclusions:
- High-speed PAM is a rapidly developing field with substantial biomedical potential.
- Continued innovation in PAM technology promises to enhance functional imaging capabilities.
- Further advancements will broaden the applications of PAM in various medical research areas.
