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Optoacoustic brain imaging: A systematic review and field mapping
Yikai Wang1, Amir Khansari2, Qingxiang Ding1
1Institute of Precision Optical Engineering, School of Physics Science and Engineering, Tongji University, Shanghai, China.
Photoacoustics
|July 28, 2026
Summary
Optoacoustic (OA) imaging combines light and sound for high-resolution brain scans. This review covers OA technology, applications in neurological disorders, and future research directions for neuroimaging.
Area of Science:
- Neuroimaging
- Biomedical Optics
- Medical Physics
Background:
- Optoacoustic (OA) imaging offers hybrid optical-ultrasonic contrast for brain studies.
- It surpasses optical diffusion limits while retaining molecular sensitivity.
- OA imaging maps vasculature, hemodynamics, and metabolism across scales.
Purpose of the Study:
- To systematically review technological advances and biomedical applications of OA brain imaging.
- To provide a quantitative overview of the research landscape and publication trends.
- To identify challenges and future directions in OA neuroimaging.
Main Methods:
- Systematic review of worldwide research activity in OA brain imaging.
- Analysis of publication trends, geographical distribution, and technological advancements.
- Review of multimodal platforms and applications in animal models of neurological disorders.
Main Results:
- Mapping of research development, including geographical distribution and publication trends.
- Summary of advances in OA microscopy, tomography, and multimodal imaging platforms.
- Review of OA imaging applications in animal models for disease biomarkers and therapy.
Conclusions:
- OA imaging is a powerful tool for multi-scale neuroimaging, from microvasculature to whole-brain volumes.
- Emerging multimodal platforms enhance multiparametric interrogation of brain dynamics.
- Key challenges include spectral quantification, transcranial imaging, standardization, and clinical translation.
