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Updated: Oct 22, 2025
07:44
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
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Pyroptosis, metabolism, and tumor immune microenvironment
Tiantian Du1, Jie Gao1, Peilong Li1
1Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Clinical and Translational Medicine
|August 30, 2021
Summary
Pyroptosis, an inflammatory cell death, is executed by gasdermin proteins. Its role in metabolic diseases and tumors depends on context, offering potential therapeutic targets.
Area of Science:
- Cellular Biology
- Immunology
- Pathology
Background:
- Pyroptosis is an inflammatory cell death pathway triggered by cytosolic danger signals and infections.
- Gasdermin (GSDM) proteins are key executors of pyroptosis, determining cell fate.
- The impact of pyroptosis on host health and immunity is context-dependent.
Purpose of the Study:
- To systematically review the regulatory mechanisms of pyroptosis.
- To explore the multidimensional roles of pyroptosis in metabolic diseases.
- To investigate the involvement of pyroptosis in the tumor microenvironment.
Main Methods:
- Systematic literature review.
- Analysis of regulatory pathways of pyroptosis.
- Examination of pyroptosis's role in disease models.
Main Results:
- Gasdermin cleavage is central to pyroptosis execution.
- Pyroptosis has context-specific effects on host defense and pathology.
- Pyroptosis is implicated in metabolic diseases and the tumor microenvironment.
Conclusions:
- Understanding pyroptosis regulation is crucial.
- Pyroptosis plays complex roles in metabolic diseases and cancer.
- Targeting pyroptosis presents potential therapeutic strategies.
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