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Related Experiment Video

Updated: Oct 22, 2025

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research
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Microfluidic Organs-on-a-Chip for Modeling Human Infectious Diseases.

Yaqing Wang1, Peng Wang1, Jianhua Qin1,2,3,4

  • 1Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Accounts of Chemical Research
|August 30, 2021
PubMed
Summary

Organ chips offer advanced in vitro models for studying infectious diseases like COVID-19. These microphysiological systems improve understanding of virus-host interactions and accelerate therapeutic development.

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Area of Science:

  • Biomedical Engineering
  • Infectious Disease Research
  • Microfluidics

Background:

  • Infectious diseases, including COVID-19, pose significant public health challenges.
  • Current in vitro models and animal studies lack human physiological relevance.
  • Organ-on-a-chip technology offers a promising solution for disease modeling.

Purpose of the Study:

  • To review advancements in organ-on-a-chip technology for infectious disease research.
  • To highlight the application of organ chips in studying SARS-CoV-2 and intrauterine infections.
  • To discuss the potential of lung-on-a-chip and intestine-on-a-chip models for COVID-19 research.

Main Methods:

  • Utilizing microfluidic devices lined with living cells to mimic organ-level physiology.
  • Recreating tissue-tissue interfaces, mechanical cues, fluidic flow, and biochemical microenvironments.
  • Employing organ chips and microphysiological systems to model viral and bacterial infections.

Main Results:

  • Organ chips successfully replicate complex pathophysiological features of human infections in vitro.
  • Lung-on-a-chip and intestine-on-a-chip models show utility in studying COVID-19.
  • These models facilitate the study of virus-host interactions and human-relevant responses.

Conclusions:

  • Organ chips provide a valuable platform for disease pathogenesis studies and drug testing.
  • Further development of organ chips is crucial for combating infectious diseases and pandemics.
  • Interdisciplinary collaboration is essential for advancing organ chip technology in infection research.