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Elements of Th1/Th2 response and disease severity in COVID-19 patients: A short report
Karolina Akinosoglou1,2, Anne-Lise Delastic1, Vasilina Dimakopoulou1
1Department of Internal Medicine, University of Patras, Rio, Greece.
Abstract:
The presence of a complex immune dysregulation syndrome has been established in COVID-19 patients. We aimed to assess Th1/Th2 response in COVID-19 patients and its association with disease severity by performing a prospective cohort study in a tertiary hospital COVID-19 referral center. We report no difference between Th1/Th2 responses between patients with severe and mild disease, except for levels of interleukin-6 (IL-6) and IL-10. Future larger studies should examine lung-specific versus systemic inflammatory responses, as well as, diverse immunotypes driving poor clinical outcomes.
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