The changing face of neonatal intensive care for infants born extremely preterm (<28 weeks' gestation)

Lex W Doyle1, Brian A Darlow2

  • 1Department of Obstetrics & Gynaecology, University of Melbourne, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Research Office, Royal Women's Hospital, Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia.

Seminars in Perinatology
|August 31, 2021
PubMed

Insights

Neonatal intensive care for extremely preterm infants has evolved significantly, with survival rates increasing due to advancements in treatments and evidence-based practices. Learning from past errors is crucial for future improvements in infant care.

Area of Science:

  • Neonatology
  • Pediatric Intensive Care

Background:

  • Neonatal intensive care for extremely preterm infants (<28 weeks' gestation) has undergone substantial transformation over the last 60-70 years.
  • Early 20th-century care had limited survival rates, contrasting with the increasing survival observed in the latter half and into the 21st century.

Purpose of the Study:

  • To review pivotal changes in neonatal intensive care for extremely preterm infants.
  • To analyze the consequences of these changes and identify lessons learned from past mistakes.

Main Methods:

  • Historical review of neonatal intensive care practices.
  • Discussion of evolving attitudes, physical environments, staffing, and core treatments like oxygen therapy and assisted ventilation.
  • Emphasis on the integration of evidence-based care.

Main Results:

  • Dramatic improvements in survival rates for extremely preterm infants.
  • Identification of critical shifts in care approaches, including changes in medical interventions and care delivery models.
  • Recognition that past interventions, while improving survival, also led to unintended negative consequences.

Conclusions:

  • Neonatal intensive care continues to advance, driven by ongoing research and technological innovation.
  • Learning from historical successes and failures is essential to prevent repeating past mistakes.
  • Future evolution of neonatal intensive care must prioritize patient safety and optimize long-term outcomes for extremely preterm infants.