Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.

BMC medicine·2026

Same author

From Therapeutic Heterogeneity to Precision Neuromodulation: Non-Invasive Brain Stimulation for Chronic Insomnia.

Nature and science of sleep·2026

Same author

Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.

Neurochemical research·2026

Same author

Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.

CNS neuroscience & therapeutics·2025

Same author

Severe relapse after cessation of immunosuppressive therapy in a patient with co-occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report.

Ibrain·2025

Same author

Insomnia Comorbid With Depression: A Bibliometric and Visualized Analysis of Research Trends and Hotspots From 2000 to 2024.

Behavioural neurology·2025

Search research articles

Related Experiment Video

Updated: Oct 22, 2025

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Non-hyperammonaemia valproate-induced encephalopathy: A case report.

Ling Chen¹, Zucai Xu¹, Hao Huang¹

¹Department of Neurology, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Journal of Clinical Pharmacy and Therapeutics

|August 31, 2021

Summary

Valproate sodium can cause encephalopathy without high ammonia levels. Discontinuing this antiepileptic drug rapidly resolves symptoms, highlighting the importance of early diagnosis.

Keywords:

adverse effect encephalopathy epilepsy non-hyperammonaemia valproate sodium

More Related Videos

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Oct 22, 2025

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Area of Science:

Neurology
Pharmacology

Background:

Valproate sodium is a widely used antiepileptic drug (AED).
Serious adverse effects are rare, but valproate-induced encephalopathy can occur.

Observation:

A case of a 47-year-old woman with epilepsy who developed valproate-induced encephalopathy.
This encephalopathy occurred without hyperammonaemia.
Symptoms resolved completely after valproate sodium withdrawal.

Findings:

Valproate-induced encephalopathy can manifest without hyperammonaemia.
Discontinuation of valproate sodium leads to rapid symptom resolution.

Implications:

Early diagnosis of non-hyperammonaemic valproate-induced encephalopathy is crucial.
Understanding the mechanisms is important for patient management.
Prompt withdrawal of valproate sodium is key for recovery.