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Updated: Oct 22, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

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Contrast‑induced acute kidney injury in COVID-19 patients

M Gucun, M E Isik

    Bratislavske Lekarske Listy
    |August 31, 2021
    PubMed

    Insights

    Patients with COVID-19 undergoing coronary angiography face a high risk of contrast-induced acute kidney injury (CI-AKI). Lower pre-procedure e-GFR, albumin, and ejection fraction were associated with CI-AKI development.

    Area of Science:

    • Cardiology
    • Nephrology
    • Infectious Diseases

    Background:

    • COVID-19 is associated with cardiovascular complications, including acute coronary syndrome.
    • Percutaneous coronary intervention (PCI) is a common treatment for acute coronary syndrome.
    • Contrast media used in angiography can precipitate kidney injury, particularly in vulnerable patients.

    Purpose of the Study:

    • To investigate the incidence and risk factors of contrast-induced acute kidney injury (CI-AKI) in COVID-19 patients undergoing emergency PCI.
    • To identify clinical parameters associated with CI-AKI development in this specific patient population.

    Main Methods:

    • A cohort of 42 COVID-19 patients undergoing emergency PCI for acute coronary syndrome was studied.
    • CI-AKI was defined as an increase in serum creatinine by 0.3 mg/dL within 48 hours of contrast exposure.
    • Patients were stratified into CI-AKI and non-CI-AKI groups for comparative analysis.

    Main Results:

    • CI-AKI developed in 33.3% of the studied COVID-19 patients.
    • Lower pre-procedure estimated glomerular filtration rate (e-GFR), serum albumin, and ejection fraction were significantly associated with CI-AKI.
    • The platelet/lymphocyte ratio was significantly lower in patients who did not develop CI-AKI.

    Conclusions:

    • COVID-19 patients undergoing coronary angiography exhibit a high risk of developing CI-AKI.
    • Pre-existing renal compromise, lower cardiac function, and altered inflammatory markers are associated with CI-AKI in this cohort.
    Abstract

    Keywords:
    COVID-19contrast-induced acute kidney injury coronary angiography.

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