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Updated: Oct 22, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology
Jian-Hong Qi1, Fang-Xu Dong2, Xiao-Long Wang3,4,5
1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Changqing University of Science and Technology Park, Changqing District, Jinan, 250355, Shandong, China. qjh951024@163.com.
Abstract:
Paeonol, derived from natural plants (Moutan Cortex), has a wide range of biological effects, including anti-inflammatory and antitumor effects as well as favorable effects against cardiovascular and neurodegenerative diseases. The anti-inflammatory action is the main pharmacological activity of paeonol and has the greatest clinical relevance. However, the anti-inflammatory mechanism of paeonol has not been reported in sufficient detail. We systematically analyzed the anti-inflammatory mechanism of paeonol using network pharmacological databases and platforms, including TCMSP, Swiss TargetPrediction, OMIM, DrugBank, TTD, Jevnn, STRING11.0, and Metascape. Furthermore, we used high-throughput molecular docking method to prove the results of the above analyses, providing a reference for exploring the mechanism of paeonol and developing targeted drugs.
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