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Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?
Ramazan Dertli1, Mehmet Asil1, Murat Bıyık1
1Division of Gastroenterology, Department of Internal Medicine, Necmettin Erbakan University, Meram School of Medicine, Meram, Konya, Turkey.
Summary
Toll-like receptor 1 (TLR1) rs5743551 polymorphism is linked to hepatocellular carcinoma (HCC) development. This genetic factor may increase HCC risk in cirrhotic patients through chronic inflammation driven by bacterial translocation.
Area of Science:
- Immunology
- Genetics
- Hepatology
Background:
- Hepatocellular carcinoma (HCC) is a major cause of cancer mortality.
- Toll-like receptors (TLRs) play crucial roles in liver pathophysiology, including immune regulation and carcinogenesis.
- Genetic variations in TLRs may influence HCC susceptibility and clinical presentation.
Purpose of the Study:
- To investigate the association between Toll-like receptor 1 (TLR1) and nucleotide-binding oligomerization domain (NOD2) polymorphisms and the development of HCC.
- To evaluate the impact of these polymorphisms on the clinical characteristics of HCC patients.
Main Methods:
- Prospective study including cirrhotic and HCC patients.
- Data collected: sex, age, cirrhosis etiology, Child-Pugh class, MELD scores.
- TLR1 (rs4833095, rs5743551) and NOD2 (rs2066844, rs2066845, rs2066847) polymorphisms analyzed using PCR.
Main Results:
- HCC developed in 31.4% of 280 followed-up patients.
- TLR1 (rs5743551) polymorphism showed a significant association with HCC development (P = .003).
- TLR1 (rs5743551) and NOD2 (rs2066844) polymorphisms were associated with spontaneous bacterial peritonitis (SBP) in HCC patients (P = .013 and P = .021, respectively).
Conclusions:
- Increased bacterial translocation in cirrhotic patients may promote HCC development via chronic inflammation.
- TLR1 (rs5743551) polymorphism appears to be a significant risk factor for HCC in this context.
