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Multicentric Hospital-Based Surveillance of Pertussis Amongst Infants Admitted in Tertiary Care Facilities in India

A Apte1, R Shrivastava1, S Sanghavi1

  • 1Department of Pediatrics, KEM Hospital Research Centre, Pune, India.

Indian Pediatrics
|September 1, 2021
PubMed

Insights

Pertussis (whooping cough) significantly burdens hospitalised infants in India, particularly younger, preterm, and unvaccinated infants. Immunisation is key to reducing this disease burden.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Pertussis poses a significant health threat to infants globally.
  • Estimating the burden of pertussis in hospitalized infants is crucial for public health interventions in India.

Purpose of the Study:

  • To determine the disease and economic burden of pertussis among hospitalized infants in India.
  • To identify risk factors associated with pertussis infection in this population.

Main Methods:

  • A multicenter hospital-based surveillance study was conducted.
  • Infants with clinical suspicion of pertussis were recruited based on predefined criteria.
  • Laboratory confirmation and economic impact assessment were performed.

Main Results:

  • Out of 693 suspected infants, 32 (4.62%) had laboratory-confirmed pertussis.
  • Common presentations included cough with emesis and pneumonia; apnea was associated with pertussis.
  • Pertussis cases were younger, more likely preterm, and often inadequately immunized, incurring higher hospitalization costs.

Conclusions:

  • Younger, preterm, and inadequately immunized infants are at higher risk for pertussis.
  • Timely childhood immunization and maternal immunization are recommended to reduce pertussis burden.
  • Pertussis significantly impacts healthcare costs and caregiver productivity.
Abstract

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