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EFFECTS OF IRISIN ON REPRODUCTIVE HORMONES, LIPID PROFILES, AND OXIDATIVE STRESS BIOMARKERS IN MALE RATS.

B Shokrollahi1, M Ibrahim Kwekha Zandi2, A Palani3

  • 1Subtropical Livestock Research Center, National Institute of Animal Science, RDA, Jeju, Korea.

Acta Endocrinologica (Bucharest, Romania : 2005)
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Summary

Irisin administration in male rats boosted reproductive hormones and sperm production while improving antioxidant capacity. This suggests irisin may help manage male reproductive health issues, especially those linked to oxidative stress.

Keywords:
IrisinMetabolic factorsOxidative stressReproductive hormonesSpermatogenesis

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Metabolism

Background:

  • Irisin, derived from FNDC5, is linked to energy metabolism and reproductive regulation.
  • Its role in male reproductive function and oxidative balance requires further investigation.

Purpose of the Study:

  • To assess the effects of irisin on endocrine, antioxidant, and reproductive parameters in male rats.
  • To determine irisin's potential as a therapeutic agent for male reproductive dysfunction.

Main Methods:

  • Male Wistar rats received subcutaneous irisin (200 ng/kg) or saline over 30 days.
  • Hormonal (GnRH, LH, FSH, testosterone), lipid, and oxidative stress markers (MDA, ROS, TAC) were measured.
  • Sperm count, motility, and morphology were evaluated.

Main Results:

  • Irisin significantly increased GnRH, LH, FSH, and testosterone levels, activating the HPG axis.
  • Oxidative stress markers improved, with decreased MDA and ROS and increased TAC.
  • Sperm count increased, but motility and morphology remained unaffected. Lipid profiles were unchanged.

Conclusions:

  • Subcutaneous irisin administration positively impacts male rat reproductive hormones and antioxidant status.
  • Irisin shows potential as a therapeutic agent for male reproductive function, particularly in cases of oxidative stress or endocrine disruption.