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Diagnosing hepatic encephalopathy (HE) is challenging. This study found that speech patterns, including speech rate and word duration, can serve as potential biomarkers for HE in patients with cirrhosis.

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Area of Science:

  • Neurology
  • Speech-Language Pathology
  • Gastroenterology

Background:

  • Hepatic encephalopathy (HE) lacks simple diagnostic tools.
  • Current methods for diagnosing and grading HE are burdensome.
  • There is a need for point-of-care tests for HE.

Purpose of the Study:

  • To investigate speech as a potential biomarker for HE.
  • To correlate speech features with HE severity.
  • To explore low-burden diagnostic methods for HE.

Main Methods:

  • Evaluated speech patterns in 76 adults with cirrhosis.
  • Analyzed speech rate, word duration, and particle usage.
  • Correlated speech features with neuropsychiatric scores.

Main Results:

  • Slower speech rate (22-23 words/min) correlated with lower neuropsychiatric scores and HE history.
  • Longer word duration (0.09 sec/word) was associated with HE.
  • Reduced particle usage (0.85%) linked to HE severity.

Conclusions:

  • Speech features like rate and duration are potential biomarkers for HE.
  • Speech analysis offers a low-burden approach to assess HE.
  • Speech biomarkers could aid in diagnosing and grading HE.