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Related Experiment Video

Updated: Oct 22, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

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Cure and Hormonal Control After Prolactinoma Resection: Case Series and Systematic Review.

Marisa C Penn1, Tyler Cardinal1, Yanchen Zhang1

  • 1Department of Neurosurgery, Keck School of Medicine of USC, Los Angeles, California 90033, USA.

Journal of the Endocrine Society
|September 1, 2021
PubMed
Summary

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Journal of neuro-oncology·2026

Surgical resection of prolactinomas offers a safe and effective treatment option for patients intolerant to medication. Predictors like tumor size and preoperative prolactin levels can help determine the likelihood of successful surgical outcomes.

Area of Science:

  • Neurosurgery
  • Endocrinology
  • Oncology

Background:

  • Surgical management of prolactinomas is a key treatment for patients unresponsive to dopamine agonists.
  • Predictors for successful surgical outcomes in prolactinoma patients remain largely undefined.

Purpose of the Study:

  • To identify predictors of surgical cure and biochemical remission after transsphenoidal surgical resection (TSSR) for prolactinomas.
  • To evaluate the efficacy and safety of TSSR as a second-line therapy for prolactinoma.

Main Methods:

  • Retrospective review of prolactinoma patients undergoing TSSR from 1995-2020.
  • Systematic review of outcomes for surgically managed prolactinomas.
  • Categorization of patients based on surgical cure and biochemical control.
Keywords:
neurosurgerypituitary adenomapituitary tumorprolactinoma

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Last Updated: Oct 22, 2025

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Main Results:

  • Surgical cure was achieved in 46% of patients, with biochemical control in 64%.
  • Smaller, noninvasive tumors, complete resection, and lower preoperative prolactin levels (<1000 ng/mL) predicted surgical cure.
  • Adjuvant therapy success was lower in men and those with invasive tumors or high prolactin levels.

Conclusions:

  • Transsphenoidal surgical resection is a safe and effective treatment for prolactinomas, achieving symptom and/or biochemical control in most patients.
  • Several predictors can help guide patient selection and counseling for TSSR outcomes.