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Cannabinol and Sleep: Separating Fact from Fiction.
1The Center for Medical Cannabis Education, Del Mar, California, USA.
Cannabis and Cannabinoid Research
|September 1, 2021
Summary
Claims that cannabinol (CBN) promotes sleep lack scientific backing. Current research is limited and outdated, with no robust clinical trials demonstrating CBN
Area of Science:
- Pharmacology
- Sleep Medicine
- Cannabinoid Research
Background:
- Cannabis marketers claim cannabinol (CBN) has unique sleep-promoting effects.
- Plausible mechanisms exist, but claims may stem from anecdotal evidence or "cannabis lore."
Purpose of the Study:
- To determine if sufficient clinical evidence supports the sleep-promoting claims of cannabinol (CBN).
Main Methods:
- Systematic literature search of PubMed/MEDLINE.
- Screened 99 human study abstracts, reviewed 8 full-text articles.
- Focused on pre-clinical and clinical research on CBN's effects, particularly on sleep.
Main Results:
- Existing research on CBN is dated, limited, and features small, non-diverse study populations.
- Few studies specifically assessed subjective sleep effects like sedation.
- No published clinical trials were identified linking CBN to validated sleep questionnaires or polysomnography.
- Evidence for CBN eliciting cannabis-like effects in humans is mixed, with most data showing no such effect.
Conclusions:
- Insufficient published evidence supports the sleep-related claims for cannabinol (CBN).
- Randomized controlled trials are necessary to validate manufacturer claims.
- Future trials should use polysomnography or validated sleep questionnaires and higher dosages than typically found in commercial products.
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