Advances in Research on Bladder Cancer Targeting Peptides: a Review

Area of Science:

• Oncology
• Biotechnology
• Urology

Background:

• Bladder cancer (Bca) is a prevalent genitourinary malignancy in Chinese males, characterized by high recurrence and progression rates.
• Despite decades of research, the prognosis for Bca has seen limited improvement due to the absence of effective early theranostic techniques.
• Current intravesical theranostic approaches for Bca suffer from poor clinical outcomes attributed to insufficient tumor-targeting efficiency.

Purpose of the Study:

• To systematically review the application of targeting peptides in intravesical theranostic techniques for bladder cancer.
• To provide a comprehensive summary of original research on targeting peptides for Bca.
• To explore peptide screening, targeting mechanisms, and preclinical applications for Bca theranostics.

Main Methods:

• Systematic review of original research studies.
• Analysis of peptide screening methodologies for Bca targeting.
• Evaluation of targeting mechanisms and preclinical applications of peptides in Bca models.

Main Results:

• Targeting peptides demonstrate potential to enhance tumor-targeting efficiency in intravesical Bca theranostics.
• Various peptide screening strategies have been employed to identify Bca-specific peptides.
• Preclinical studies highlight the feasibility of using targeting peptides for Bca diagnosis and therapy.

Conclusions:

• Targeting peptides represent a significant advancement for improving intravesical theranostic techniques in bladder cancer.
• Further research and clinical translation of these peptides are warranted to improve Bca patient prognosis.
• The development of effective targeting peptides could revolutionize early detection and treatment of bladder cancer.