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Distinct Causal Influences of Dorsolateral Prefrontal Cortex and Posterior Parietal Cortex in Multiple-Option
Tsz-Fung Woo1, Chun-Kit Law1, Kin-Hung Ting2
1Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong.
Enhancing the dorsolateral prefrontal cortex (dlPFC) improved decision-making with many options by filtering irrelevant information. The posterior parietal cortex (PPC) influenced choices by emphasizing contralateral options.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Decision Science
Background:
- Decision-making research often uses limited options, unlike real-life scenarios with multiple choices.
- Selective information processing is crucial for complex, multi-option decisions.
- The roles of the dorsolateral prefrontal cortex (dlPFC) and posterior parietal cortex (PPC) in such decisions are not fully understood.
Purpose of the Study:
- To investigate the causal roles of dlPFC and PPC in multiple-option decision-making.
- To determine if enhancing dlPFC or PPC with transcranial direct current stimulation (tDCS) affects decision strategies.
Main Methods:
- Sixty-eight participants underwent anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting either dlPFC or PPC.
- A double-blind, sham-controlled design was employed.
- Participants completed a decision-making task involving multiple options.
Main Results:
- Longer fixation times on suboptimal choices correlated with poorer decision outcomes.
- Anodal HD-tDCS over dlPFC attenuated the negative impact of fixating on poor options, particularly with numerous choices.
- Anodal HD-tDCS over PPC led to choices biased towards contralateral best options, suggesting a role in spatial value-based selection.
Conclusions:
- The dlPFC causally contributes to filtering out undesirable options during complex decision-making.
- The PPC causally influences decision-making by biasing selection towards desirable contralateral options.
- These findings differentiate the specific roles of dlPFC and PPC in navigating multiple-choice scenarios.
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