New approach to the use of propolis against dermatomycosis

Area of Science:

• Mycology
• Pharmacology
• Biomaterials Science

Background:

• Propolis extract (PE) exhibits known antimicrobial and anti-inflammatory effects.
• Dermatomycosis treatment often requires effective agents against various fungal strains and biofilms.

Purpose of the Study:

• To assess the antifungal efficacy of a 16% propolis-containing bioadhesive thermoresponsive system (BTSP 16%) against key dermatophyte species.
• To compare the activity of BTSP 16% with propolis extract (PE) alone.
• To investigate the interaction of BTSP 16% with fungal biofilms at different developmental stages.

Main Methods:

• In vitro evaluation of antifungal activity against *Microsporum canis*, *Nannizzia gypsea*, *Trichophyton mentagrophytes*, and *T. rubrum*.
• Assessment of propolis extract (PE) and BTSP 16% on fungal viability.
• Analysis of the interaction between BTSP 16% and fungal biofilms during formation and in mature states.

Main Results:

• Both PE and BTSP 16% demonstrated significant reduction in fungal viability across all tested strains.
• BTSP 16% effectively interacted with fungal biofilms, impacting various stages of their formation.
• The bioadhesive and thermoresponsive nature of BTSP 16% enhanced the sustained presence of propolis at infection sites.

Conclusions:

• BTSP 16% offers a promising alternative therapeutic option for dermatomycosis.
• The formulation's unique properties contribute to its efficacy against both planktonic fungal cells and mature biofilms.
• Further research into advanced delivery systems for natural compounds like propolis is warranted.