Related Experiment Video
Updated: Oct 21, 2025

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
Exercise-Induced Left Bundle Branch Block Resulting in Severe Mitral Regurgitation
Brenden S Ingraham1, Panithaya Chareonthaitawee1, Yogesh N V Reddy1
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Exercise hemodynamic catheterization aids in diagnosing exertional symptoms in non-ischemic cardiomyopathy. Cardiac resynchronization therapy effectively resolved symptoms caused by a rate-related left bundle branch block.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Non-ischemic cardiomyopathy presents diagnostic challenges for exertional symptoms.
- Noninvasive investigations may not fully elucidate the cause of symptoms.
Observation:
- A patient with non-ischemic cardiomyopathy experienced exertional symptoms.
- A rate-related left bundle branch block was identified as the cause.
Findings:
- The left bundle branch block induced severe dynamic mitral regurgitation.
- This led to an acute increase in pulmonary capillary wedge pressure.
Implications:
- Exercise hemodynamic catheterization is a valuable tool when noninvasive methods fail.
- Cardiac resynchronization therapy can effectively manage symptoms in such cases.
More Related Videos
08:42Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
Published on: February 11, 2022
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Related Concept Videos
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation III: Medical Management
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation IV: Nursing Management