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[Bibenzyls from Dendrobium officinale].

Yu-Juan Zhou1, Jun-Hao Wang1, Hong Xu1

  • 1The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, The State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 2, 2021
PubMed
Summary

This study isolated fifteen bibenzyls from Dendrobium officinale stems, including one novel compound and several new to Dendrobium species. These findings expand the known chemical diversity of this important medicinal plant.

Keywords:
Dendrobium officinalebibenzylschemical constituentsdendrocandin X

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Medicinal Plant Research

Background:

  • Dendrobium officinale is a valuable traditional Chinese medicine.
  • Bibenzyls are a class of compounds with potential biological activities.
  • Understanding the chemical constituents of D. officinale is crucial for its medicinal applications.

Purpose of the Study:

  • To isolate and identify bibenzyl compounds from Dendrobium officinale stems.
  • To characterize novel and previously unreported compounds from this species.
  • To contribute to the phytochemical knowledge of D. officinale.

Main Methods:

  • Extraction of Dendrobium officinale stems using ethyl acetate.
  • Extensive chromatographic techniques including macroporous resin, MCI, silica gel, Sephadex LH-20, ODS column chromatography, preparative thin-layer chromatography, and preparative High-Performance Liquid Chromatography (HPLC).
  • Structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy (¹H-NMR, ¹³C-NMR) and Mass Spectrometry (MS), supported by physical and physicochemical properties.

Main Results:

  • Fifteen bibenzyl compounds were successfully isolated and purified.
  • Compound 1 (dendrocandin X) was identified as a novel bibenzyl.
  • Compound 2 was reported from Dendrobium species for the first time.
  • Compounds 3-7 were isolated from D. officinale for the first time, enriching the known phytochemistry of the plant.

Conclusions:

  • The phytochemical investigation of Dendrobium officinale stems yielded a diverse array of bibenzyls.
  • The discovery of a novel compound and several new compounds for the species highlights the chemical richness of D. officinale.
  • These findings provide a foundation for further research into the biological activities and medicinal potential of these isolated bibenzyls.