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Related Experiment Videos

Oxygen therapy and intraocular oxygenation.

L M Jampol1

  • 1Department of Ophthalmology, Northwestern University Medical School, Chicago, IL.

Transactions of the American Ophthalmological Society
|January 1, 1987
PubMed
Summary

High oxygen levels delivered to the eye can increase oxygen in the aqueous humor, potentially treating sickle cell hyphema and ischemic retinal diseases.

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Area of Science:

  • Ophthalmology
  • Physiology
  • Hyperbaric Medicine

Background:

  • Elevated intraocular oxygen levels are crucial for treating certain eye conditions.
  • Sickle cell disease can affect the eye, leading to hyphema and vision loss.
  • Ischemic retinal diseases pose a significant threat to vision.

Purpose of the Study:

  • To investigate the effects of transcorneal and systemic oxygen delivery on intraocular oxygen levels.
  • To evaluate the potential of oxygen therapy for sickle cell hyphema and ischemic eye diseases.

Main Methods:

  • Administering 100% oxygen to the corneal surface of rabbits and monkeys.
  • Utilizing hyperbaric conditions (two atmospheres) to enhance oxygen delivery.
  • Measuring partial pressure of oxygen (pO2) in the aqueous humor and vitreous.

Main Results:

  • 100% oxygen significantly increased aqueous humor pO2 in rabbits and monkeys.
  • Hyperbaric oxygen further elevated aqueous pO2 in rabbits.
  • Increased oxygen levels prevented sickling of human erythrocytes in vitro.
  • Hyperbaric oxygen raised preretinal vitreous pO2 levels in monkeys.
  • Iris vasculature constriction observed in rabbits, but not in humans.

Conclusions:

  • Transcorneal or systemic oxygen delivery can increase intraocular oxygen levels.
  • Oxygen therapy shows potential for treating sickle cell hyphema.
  • Hyperbaric oxygen therapy may benefit patients with acute ischemic inner retinal diseases.
  • Oxygen delivery strategies could be valuable for anterior segment and retinal ischemic conditions.

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