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Updated: Oct 21, 2025

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Published on: December 28, 2012

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Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data - United States, March

Tegan K Boehmer, Lyudmyla Kompaniyets, Amy M Lavery

    MMWR. Morbidity and Mortality Weekly Report
    |September 2, 2021
    PubMed

    Insights

    COVID-19 significantly increases the risk of myocarditis (heart muscle inflammation), with risk varying by age. This highlights the importance of COVID-19 prevention strategies like vaccination.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Public Health

    Background:

    • Myocarditis, an inflammation of the heart muscle, is often caused by viral infections.
    • Emerging evidence suggests a link between COVID-19 and myocarditis.
    • Myocarditis can lead to severe outcomes including hospitalization, heart failure, and sudden death.

    Purpose of the Study:

    • To assess the association between COVID-19 and myocarditis.
    • To quantify the risk of myocarditis in patients with and without COVID-19.
    • To examine age-specific risks of myocarditis in the context of COVID-19.

    Main Methods:

    • Utilized a large U.S. hospital-based administrative database covering over 900 hospitals.
    • Analyzed inpatient encounters for myocarditis from 2019 and 2020.
    • Compared myocarditis risk between patients diagnosed with COVID-19 and those without during March 2020-January 2021, adjusting for patient and hospital factors.

    Main Results:

    • Myocarditis inpatient encounters increased by 42.3% in 2020 compared to 2019.
    • Patients with COVID-19 had a 15.7 times higher risk of myocarditis compared to those without.
    • The risk ratio for myocarditis varied significantly by age, being higher in younger (<16 years) and older (≥75 years) groups.

    Conclusions:

    • COVID-19 is significantly associated with an increased risk of myocarditis.
    • The risk of myocarditis associated with COVID-19 varies across different age groups.
    • Implementing COVID-19 prevention strategies, including vaccination, is crucial to mitigate public health impacts and complications like myocarditis.

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