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Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery
Yang Li1, Shengnan Liu2, Min Liang3
1Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai, Tianjin 300072, P. R. China. qingzhi@tju.edu.cn.
Chemical Communications (Cambridge, England)
|September 2, 2021
Abstract:
Fluorescently labeled calix[4]arene glycoconjugates demonstrate multifunctional potential in both Warburg effect mediated tumor imaging and GLUT1 targeted drug delivery. Nitrobenzoxadiazole and mannose conjugated NBD-Man-CA was found to be selectively recognized by GLUT1 and act as a "molecular carrier" for selective tumor targeting.
