Related Experiment Video
Updated: Oct 21, 2025
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
3D speckle tracking echocardiographic strain pattern in Hypertrophic Cardiomyopathy and its relation with Sudden
K Rakesh1, Gopalan Nair Rajesh1, Haridasn Vellani1
1Department of Cardiology, Government Medical College, Kozhikode, Kerala, 673008, India.
Insights
3D speckle tracking echocardiography reveals reduced strain parameters in Hypertrophic cardiomyopathy (HCM) patients. These deformation indices correlate with sudden cardiac death (SCD) risk markers, aiding in risk stratification for HCM patients.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Predicting sudden cardiac death (SCD) in Hypertrophic cardiomyopathy (HCM) is challenging despite conventional risk markers.
- The role of myocardial deformation indices in SCD risk stratification for HCM is underexplored.
Purpose of the Study:
- To analyze 3D speckle tracking echocardiographic strain parameters in HCM patients.
- To investigate the relationship between these strain parameters and established SCD risk markers.
Main Methods:
- A cross-sectional observational study involving 50 HCM patients and age/gender-matched controls.
- Analysis of global LV strain parameters: GLS, GCS, GRS, and GAS using 3D speckle tracking.
- Correlation of strain parameters with conventional SCD risk markers and the ESC SCD risk score.
Main Results:
- HCM patients exhibited significantly lower global strain parameters (GLS, GCS, GRS, GAS) compared to controls (p < 0.001 for all).
- Subgroup analysis revealed further reductions in strain parameters in HCM patients with specific risk factors (e.g., LV thickness >30 mm, abnormal exercise test).
- Significant inverse correlations were observed between all deformation parameters and the ESC SCD risk score (p < 0.001).
Conclusions:
- A potential linear correlation exists between conventional SCD risk markers and 3D deformation parameters in HCM.
- These findings suggest that 3D strain parameters may enhance risk stratification and SCD predictability in HCM.
- Further large prospective studies are warranted for confirmation.
Context:
Sudden cardiac death (SCD) predictability for assessing the need for primary insertion of Implantable Cardioverter Defibrillator (ICD) in patients with Hypertrophic cardiomyopathy (HCM) is difficult though there are several conventional risk markers. The role of deformation indices in predicting SCD in HCM is less addressed.
Objectives:
To analyse the 3D speckle tracking echocardiographic strain parameters of HCM patients and its relation with SCD risk markers.
Design And Study Methodology:
It was a cross-sectional observation study done over a period of one year with a follow up period of one year. Fifty HCM patients were included after screening eighty-two patients. Their global LV strain parameters, Global Longitudinal Strain (GLS), Global Circumferential Strain (GCS), Global Radial Strain (GRS) and Global area strain (GAS) were analysed with respect to their age and gender-matched controls. The various strain parameters were correlated with the conventional SCD risk markers and the ESC SCD risk score among these HCM patients.
Results:
All the global strain parameters were significantly low in HCM patients compared to their controls {GLS -7.30 ± 3.424 vs -18.78 ± 2.342, p < 001; GCS -11.26 ± 2.754 vs -25.08 ± 3.542, p < 001; GRS 20.56 ± 8.929 vs 39.70 ± 7.546, p < 001}. On subgroup analysis of HCM patients with LV thickness >30 mm, abnormal exercise test, family history of SCD, LVOT gradients >30mmHgand more than one SCD risk marker had significantly low values for all global deformation parameters, when compared with their control HCM cohort. The ESC risk score also had significant inverse correlation with all deformation parameters (GLS 0.496, p < 0.001; GCS 0.491, p < 0.001; GRS -0.529, p < 0.001; GAS 0.519, p < 0.001). On follow up, only one event was recorded in this cohort.
Conclusion:
There exists a possible linear correlation between conventional SCD risk markers and 3D deformation parameters, which may be utilized for risk stratification and SCD predictability in HCM patients after confirmation with further large prospective studies.
More Related Videos
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
07:21Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies