High-resolution fast-tomography brain-imaging beamline at the Taiwan Photon Source

Area of Science:

• Synchrotron radiation science
• Biomedical imaging
• Materials science

Background:

• The Taiwan Photon Source (TPS) has introduced a new Brain Imaging Beamline (BIB).
• The BIB is designed for advanced 3D imaging using synchrotron X-rays.
• Previous limitations included X-ray induced damage to detection systems.

Purpose of the Study:

• To commission and open the Brain Imaging Beamline (BIB) for user access.
• To enable fast 3D imaging with high spatial resolution.
• To overcome challenges related to X-ray induced damage for improved performance.

Main Methods:

• Utilizing bright, unmonochromatized synchrotron X-rays.
• Implementing tailored filters/attenuators to manage X-ray energy.
• Employing a high-energy cut-off mirror to protect the detection system.

Main Results:

• Achieved fast 3D imaging with ~1 ms exposure times.
• Reached high spatial resolution of approximately 0.3 µm.
• Enabled tomography acquisition throughput exceeding 1 mm³ min⁻¹.

Conclusions:

• The Brain Imaging Beamline (BIB) at TPS is now operational for users.
• Effective mitigation of X-ray induced damage was achieved.
• The beamline's performance is critical for large-animal brain mapping research.