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Whole blood viscosity in patients with aortic stenosis

Ahmet Akdi1, Kadriye Gayretli Yayla2

  • 1University of Health Sciences, Department of Cardiology, Ankara City Hospital.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 3, 2021
PubMed

Insights

Whole blood viscosity (WBV) is linked to aortic stenosis severity. Higher WBV, measured at high shear rate (HSR) and low shear rate (LSR), independently predicts aortic stenosis progression.

Area of Science:

  • Cardiovascular Medicine
  • Rheology
  • Medical Diagnostics

Background:

  • Whole blood viscosity (WBV) contributes to endothelial shear stress and inflammation.
  • Elevated WBV is implicated in accelerating the atherosclerotic process.
  • Understanding WBV's role in valvular heart disease is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate the association between whole blood viscosity and the presence and severity of aortic stenosis.
  • To determine if WBV parameters are independent predictors of aortic stenosis severity.

Main Methods:

  • Cross-sectional study involving 209 participants.
  • Categorization into severe aortic stenosis (n=49), mild-to-moderate aortic stenosis (n=98), and control (n=62) groups.
  • Measurement of WBV at high shear rate (HSR) and low shear rate (LSR).
  • Correlation analysis with mean systolic transaortic gradient.
  • Multivariate analysis to identify independent predictors.

Main Results:

  • Significantly higher WBV values were observed in the severe aortic stenosis group for both HSR (P=0.001) and LSR (P=0.002).
  • Both HSR and LSR demonstrated a strong correlation with the mean systolic transaortic gradient (P<0.001 for both).
  • WBV at both LSR and HSR were identified as independent predictors of aortic stenosis severity (P=0.034 and P=0.049, respectively).

Conclusions:

  • A significant relationship exists between whole blood viscosity and aortic stenosis.
  • Elevated WBV is associated with increased severity of aortic stenosis.
  • WBV measurements offer potential as independent biomarkers for predicting aortic stenosis severity.

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