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Area of Science:

  • Toxicology
  • Hepatology
  • Gastroenterology

Background:

  • Herbal supplement consumption is associated with potential toxicities.
  • Kratom (Mitragyna speciosa) is increasingly popular for its pain-relieving and psychoactive effects.
  • While kratom-induced liver injury is documented, data on broader organ involvement are limited.

Observation:

  • A 37-year-old woman presented with symptoms after prolonged use of kratom-containing herbal supplements.
  • She exhibited a mixed hepatocellular and cholestatic pattern of acute liver injury.
  • The patient also developed acute kidney injury and pancolitis.

Findings:

  • Prolonged kratom use can lead to severe, multi-organ damage.
  • The observed toxicity pattern included liver, kidney, and colon injury.
  • This case demonstrates a complex presentation beyond isolated liver effects.

Implications:

  • Clinicians should consider kratom toxicity in patients with unexplained multiorgan injury.
  • Further research is needed to understand the full spectrum of kratom's adverse effects.
  • Awareness of kratom's potential harms is crucial for public health and patient safety.