Multiorgan Dysfunction Related to Kratom Ingestion
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Updated: Oct 21, 2025

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
Muhammad Zarrar Khan1, Mohannad Abou Saleh2, Motasem Alkhayyat1
1Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.
Abstract:
Consumption of herbal supplements has been linked to multiorgan toxicities. Kratom is an herbal extract that has gained popularity for its analgesic and psychotropic properties. Several cases of kratom-induced liver injury have been reported, but data on multiorgan involvement remain scarce. We present the case of a 37-year-old woman who developed a mixed hepatocellular and cholestatic pattern of acute liver injury, acute kidney injury, and pancolitis after prolonged use of kratom-containing herbal supplements.
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