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Updated: Oct 21, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

Paradoxical facilitation alongside interhemispheric inhibition.

Michel Belyk^1,2, Russell Banks³, Anna Tendera³

¹Department of Speech, Hearing and Phonetic Sciences, University College London, London, UK. belykm@gmail.com.

Experimental Brain Research

|September 3, 2021

Summary

Transcranial magnetic stimulation (TMS) studies reveal that larger motor evoked potentials (MEPs) from the conditioning stimulus (CS) paradoxically reduce interhemispheric inhibition (IHI) between motor cortices, sometimes causing facilitation.

Keywords:

Corpus callosum Experimental design Facilitation Interhemispheric inhibition Optimization Transcranial magnetic stimulation

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Area of Science:

Neuroscience
Motor Control
Brain Connectivity

Background:

The motor cortex connects hemispheres via the corpus callosum, exerting inhibitory influence.
Interhemispheric inhibition (IHI) studies investigate this pathway using transcranial magnetic stimulation (TMS).
Previous research assumed larger conditioning stimulus (CS) motor evoked potentials (MEPs) indicate stronger IHI.

Purpose of the Study:

To investigate the relationship between CS MEP amplitude and the magnitude of IHI.
To challenge the assumption that larger CS MEPs correlate with increased IHI.

Main Methods:

Neurophysiological experiments utilizing TMS to probe motor cortex pathways.
Application of conditioning stimulus (CS) and test stimulus (TS) to homologous motor cortices.
Measurement of motor evoked potentials (MEPs) in target muscles to quantify IHI.

Main Results:

A consistent, surprising finding of reduced IHI with larger CS MEPs was observed across participants.
In some cases, larger CS MEPs led to a net facilitatory effect instead of inhibition.
The observed effect was systematic and significant, contradicting initial predictions.

Conclusions:

The relationship between CS MEP amplitude and IHI is more complex than previously assumed.
Larger CS MEPs may indicate reduced, rather than increased, interhemispheric inhibition.
Further research is needed to elucidate the underlying neurophysiological mechanisms of this phenomenon.