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COVID-19, cardiovascular diseases and cardiac troponins

Chan W Kim1, Wilbert S Aronow1

  • 1Cardiology Department, & The Department of Medicine, Westchester Medical Center & New York Medical College, Valhalla, NY 10595, USA.

Future Cardiology
|September 3, 2021
PubMed

Insights

COVID-19 patients show significant myocardial injury, indicated by elevated cardiac troponin (cTn). This study explores the mechanisms behind this injury and the role of cTn as a prognostic biomarker.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • COVID-19 is associated with significant myocardial injury, evidenced by elevated serum cardiac troponin (cTn).
  • The precise mechanisms driving this cardiac damage remain incompletely understood.
  • Potential pathways include direct viral effects, systemic inflammation, and hypoxemia.

Purpose of the Study:

  • To discuss the pathological mechanisms contributing to myocardial injury in COVID-19.
  • To explore the causes of elevated cardiac troponin (cTn) in these patients.
  • To evaluate the utility of cTn as a biomarker and prognostic indicator for clinical outcomes.

Main Methods:

  • Review and synthesis of existing literature on COVID-19 and myocardial injury.
  • Discussion of proposed pathological mechanisms.
  • Analysis of the role of cardiac troponin as a biomarker.

Main Results:

  • Elevated serum cardiac troponin (cTn) is a strong indicator of myocardial injury in COVID-19.
  • Potential injury mechanisms include viral invasion, cytokine storm, hypercoagulability, and hypoxemia.
  • Elevated cTn may result from myocarditis, microangiopathy, or myocardial infarction.

Conclusions:

  • Cardiac troponin (cTn) is a valuable biomarker for assessing myocardial injury in COVID-19 patients.
  • Understanding the mechanisms of injury is crucial for patient management.
  • cTn levels may serve as a prognostic factor for clinical outcomes in COVID-19.

Keywords:
COVID-19cardiac troponincardiovascular diseases

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