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18F-FET PET/CT as a Diagnostic Tool for Brain Abscess

Seo Young Kang1, Yunejeong Jang2, Min-Sun Cho2

  • 1From the Departments of Nuclear Medicine.

Clinical Nuclear Medicine
|September 3, 2021
PubMed

Insights

A patient with sudden weakness and seizure was diagnosed with a brain abscess. 18F-FET PET/CT imaging helped differentiate the abscess from a tumor, guiding treatment.

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiology

Background:

  • Distinguishing brain abscesses from tumors is crucial for appropriate patient management.
  • Neuroimaging plays a vital role in the diagnosis of intracranial lesions.

Observation:

  • A 49-year-old male presented with acute neurological deficits and seizure, indicative of a focal brain lesion.
  • Brain MRI revealed a lobulated mass with specific characteristics suggestive of an inflammatory or neoplastic process.
  • Positron Emission Tomography/Computed Tomography (PET/CT) using 18F-FET (O-(2-[18F]fluoroethyl)-l-tyrosine) was employed for further characterization.

Findings:

  • 18F-FET PET/CT identified a cystic lesion in the left parietal lobe with characteristic FET uptake.
  • Compartmentalized uptake patterns were observed within the lesion and surrounding brain parenchyma.
  • A low target-to-background ratio and overall uptake pattern favored a diagnosis of brain abscess over a primary brain tumor.

Implications:

  • 18F-FET PET/CT can be a valuable tool in differentiating brain abscesses from tumors, especially in complex cases.
  • Accurate preoperative diagnosis impacts surgical strategy and postoperative management.
  • This case highlights the utility of advanced imaging in neuro-oncology and infectious disease.

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