Dynamic nanoassembly-based drug delivery systems on the horizon

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Nature utilizes self-assembly for complex structures and functions.
• Self-assembly is increasingly important in advanced drug delivery.
• The in vivo behavior of dynamic nanoassembly-based drug delivery systems (DNDDS) is poorly understood but critical for controlled release.

Purpose of the Study:

• To highlight nature-inspired designs, principles, and functionalities of DNDDS.
• To discuss how DNDDS are triggered by endogenous and exogenous stimuli.
• To explore biomedical applications of DNDDS for disease diagnosis and treatment.

Main Methods:

• Review of nature-inspired designs for DNDDS.
• Analysis of controllable functionalities and stimuli-responsive mechanisms.
• Discussion of DNDDS applications in various diseases.

Main Results:

• DNDDS leverage self-assembly principles for advanced drug delivery.
• Stimuli-responsive mechanisms enable spatiotemporal control of drug release.
• Tailor-made DNDDS show promise in treating tumors, neurological diseases, infections, and injuries.

Conclusions:

• Further understanding of DNDDS behavior in biological systems is crucial.
• DNDDS offer significant potential for precise diagnosis and treatment.
• Addressing current challenges will pave the way for future DNDDS advancements.