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Updated: Oct 21, 2025
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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
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Nanotechnology-based drug delivery for central nervous system disorders
Thuy Trang Nguyen1, Thi Thuy Dung Nguyen2, Tuong Kha Vo3
1Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City 700000, Viet Nam.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 3, 2021
Summary
Nanotechnology offers a promising solution for delivering drugs across the blood-brain barrier to treat central nervous system (CNS) diseases. This review explores nano-based therapeutics for neurological disorders and discusses clinical translation challenges.
Area of Science:
- Neuroscience
- Biotechnology
- Materials Science
Background:
- Drug delivery to the central nervous system (CNS) is significantly hindered by the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier.
- Neurological disorders such as Alzheimer's disease, Parkinson's disease, and ALS face therapeutic challenges due to poor drug penetration.
Purpose of the Study:
- To review recent advancements in nanotechnology-based drug delivery systems for CNS disorders.
- To highlight the potential of nanomedicine in overcoming biological barriers for neurological disease treatment.
- To discuss the challenges associated with the clinical translation of nanomedicines.
Main Methods:
- Literature review of research on nanotechnology applications in CNS drug delivery.
- Analysis of studies focusing on nano-based therapeutics for neurodegenerative diseases.
- Examination of clinical trial data and regulatory hurdles for nanomedicines.
Main Results:
- Nanotechnology platforms demonstrate potential for enhanced drug transport across the BBB.
- Various nanomaterials are being investigated for targeted delivery of therapeutics to the brain.
- Significant challenges remain in scaling up production and ensuring safety for clinical application.
Conclusions:
- Nanomedicine presents a viable strategy for improving drug delivery to the CNS.
- Further research and development are crucial to overcome clinical translation barriers.
- Successful implementation of nanotherapeutics could revolutionize the treatment of CNS disorders.
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