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MicroRNAs associated with signaling pathways and exercise adaptation in sarcopenia
Zahra Javanmardifard1, Shahnaz Shahrbanian2, Seyed Javad Mowla1
1Department of Molecular Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Life Sciences
|September 4, 2021
Summary
Sarcopenia, or age-related muscle loss, is increasingly common. This review explores microRNAs (miRNAs) and signaling pathways involved in muscle atrophy, and how exercise impacts miRNA expression in sarcopenia.
Area of Science:
- Gerontology
- Molecular Biology
- Muscle Physiology
Background:
- Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a growing concern due to increased human lifespan.
- Its molecular mechanisms are complex, involving intricate signaling pathways regulating protein synthesis and degradation.
- MicroRNAs (miRNAs) are key regulators that post-transcriptionally control gene expression and are implicated in sarcopenia development.
Purpose of the Study:
- To review the signaling pathways involved in sarcopenia.
- To examine the role of microRNAs (miRNAs) in regulating these pathways.
- To provide an overview of exercise's effects on miRNA expression in sarcopenia.
Main Methods:
- Literature review of molecular mechanisms in sarcopenia.
- Analysis of signaling pathways implicated in age-related muscle loss.
- Review of studies on microRNA (miRNA) involvement and exercise effects.
Main Results:
- Identified key signaling pathways and their regulation by microRNAs (miRNAs) in sarcopenia.
- Highlighted the role of aberrant miRNA expression in skeletal muscle mass decline.
- Summarized the impact of exercise on miRNA expression patterns relevant to sarcopenia.
Conclusions:
- MicroRNAs (miRNAs) are critical regulators in the molecular pathogenesis of sarcopenia.
- Understanding these miRNA-mediated pathways offers potential therapeutic targets.
- Exercise may modulate miRNA expression, suggesting a role in mitigating sarcopenia.
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