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Nanopore detects γ-radiation inhibited HIV-1 protease activity

Minghan Li1, Wei Li2, Yicen Xiao2

  • 1School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; Chongqing School, University of Chinese Academy of Sciences, Chongqing, 400714, China.

Biosensors & Bioelectronics
|September 4, 2021
PubMed
Summary

Gamma radiation effectively inhibits HIV-1 protease activity, significantly reducing its proteolytic function. This radiation-based inactivation shows promise as a complementary strategy for viral protein inhibition.

Keywords:
(60)Co γ-radiationEnzyme inactivationGagPol precursorHIV-1 proteaseNanopore

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