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Updated: Oct 21, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
Xiaoye Duan1,2, Weihao Wang1, Qi Pan1
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Abstract:
The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting PC, whereas insulin therapy may increase the risk of PC development. No evidence has shown that novel hypoglycemic drugs help or prevent PC. In this review, the effects of T2DM on PC development are summarized, and novel strategies for the prevention and treatment of T2DM and PC are discussed.
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