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SARS-Cov-2: Biology, Detection, Macrophage Mediated Pathogenesis and Potential Treatments
Gabriel Borges-Velez1, Lester J Rosario-Rodriguez1, Julio E Rosado-Philippi2
1Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, USA.
Insights
This review covers the biology, detection, and macrophage-mediated pathogenesis of SARS-CoV-2, the virus causing COVID-19. It also explores potential therapeutic strategies for this rapidly spreading pandemic disease.
Area of Science:
- Virology
- Immunology
- Epidemiology
Background:
- Coronavirus infectious disease 2019 (COVID-19) rapidly spread globally since December 2019.
- The causative agent, SARS-CoV-2, is a novel coronavirus similar to SARS-CoV.
- Both SARS-CoV-2 and SARS-CoV originated in bats and adapted to human hosts.
Purpose of the Study:
- To review the fundamental biology of SARS-CoV-2.
- To discuss current methods for detecting SARS-CoV-2.
- To explore macrophage-mediated pathogenesis and potential treatments for COVID-19.
Main Methods:
- Literature review of scientific publications on SARS-CoV-2 and COVID-19.
- Analysis of data on viral characteristics, disease progression, and therapeutic interventions.
Main Results:
- SARS-CoV-2 shares biological similarities with SARS-CoV, including zoonotic origins.
- Detection methods are crucial for managing the pandemic.
- Macrophage involvement in pathogenesis and various treatment strategies are under investigation.
Conclusions:
- Understanding SARS-CoV-2 biology is key to combating COVID-19.
- Effective detection and therapeutic interventions are critical for pandemic control.
- Further research into pathogenesis and treatments is warranted.
Abstract:
The respiratory disease caused by the Coronavirus infectious disease 2019 (COVID19) has spread rapidly since December 2019 in Wuhan, China. This new strain of Coronavirus is similar to the SARS Corona virus and has been termed SARS-CoV-2. Both viruses have emerged from bats and adapted to humans. On March 11, 2020 COVID19 was declared Pandemic by the WHO and as of May 1, 2020 COVID19 disease continues to grow rapidly with 3,400,595 cases and 239,583 deaths world-wide. This review describes the biology of SARSCOV2, Detection, Macrophage-Mediated Pathogenesis and Potential Treatments.
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